目的 探究家庭肠内营养(HEN)与益生菌联合应用对食管癌患者放疗后营养状况及癌因性疲乏的作用。 方法 选 取 2019 年 1 月至 2020 年 9 月在徐州医科大学附属淮安医院住院部放疗的 80 例食管癌患者为研究对象,根据随机数表法将 80 例患者分成试验组与对照组,各 40 例,试验组行 HEN 联合益生菌治疗方案,对照组仅接受常规肠内营养支持。 观察两组 营养指数、肠道菌群、癌因性疲乏及并发症情况。 结果 治疗后,试验组患者营养指数血清白蛋白、血红蛋白、前白蛋白、转铁蛋 白、肱三头肌皮褶厚度、上臂肌围水平均显著高于对照组(P<0. 05);治疗后,试验组患者双歧杆菌、乳酸杆菌、产气荚膜梭菌、 肠杆菌、肠球菌及拟杆菌数量明显高于对照组(P<0. 05);试验组疲乏患者例数显著低于对照组(P<0. 05);试验组患者发生肺 部、泌尿系统、伤口或导管感染性并发症的发病率显著低于对照组(P<0. 05)。 结论 HEN 联合益生菌可以提升食管癌患者放 疗后的营养水平,利于肠道菌群恢复,且不增加患者不适感,感染性并发症少,进而对患者生存质量有一定影响。

Objective To explore the effect of home enteral nutrition combined with probiotics on nutritional status and cancer-related fatigue in patients with esophageal cancer after radiotherapy. Method 80 patients with esophageal cancer who received radiotherapy in the inpatient department of our hospital from January 2019 to September 2020 were selected as the research objects. According to the random number table method the 80 patients were divided into the experimental group and the control group with 40 cases in each group. The group received home enteral nutrition combined with probiotics while the control group received only routine enteral nutrition support. The nutritional index intestinal flora cancer-related fatigue and complications of the two groups were observed. Result After treatment the nutritional indexes of serum albumin hemoglobin prealbumin transferrin triceps skinfold thickness and upper arm muscle circumference in the experimental group were higher than those in the control group P<0. 05 the number of Bifidobacterium Lactobacillus Clostridium perfringens Enterobacter Enterococcus and Bacteroides in the experimental group were significantly higher than those in the control group P<0. 05 . The number of fatigue patients in the experimental group was significantly lower than that in the control group P<0. 05 . The incidence of pulmonary urinary system wound or catheter infection complications in the experimental group was lower than that in the control group P<0. 05 . Conclusion Home enteral nutrition combined with probiotics can improve the nutritional level of patients with esophageal cancer after radiotherapy which is beneficial to the recovery of intestinal flora and does not increase the discomfort of patients. Quality has far-reaching significance and it is worth exploring some influences in depth.