评价口服营养补充(ONS)疗法对卵巢癌患者进行手术切除和常规静脉化疗后的营养状况以及免疫功能的影 响,提出合理的营养供给方案。 方法 采用临床随机对照试验,前瞻性选择 2018 年 1 月至 2021 年 12 月入江南大学附属医院确 诊卵巢癌患者共 102 例,均采用手术切除和常规静脉化疗。 然后随机分为对照组和试验组各 51 例,对照组采用常规营养指 导,试验组应用 ONS(Ensure ® ,250 ml,1. 06 kcal,每毫升含 0. 0356 g 蛋白质,美国雅培实验室生产)3 次/ d,连续 15 周。 比较两 组患者出院前、3 周、9 周和 15 周的体重、体质指数(BMI)、血清淋巴细胞计数、红细胞计数、血红蛋白、白蛋白和总蛋白水平, 以及患者主观整体评估(PG-SGA)评分。 结果 对照组 48 例和试验组 49 例最终完成临床随访。 两组患者的一般临床资料具 有可比性(P>0. 05)。 试验组随访 9 周和 15 周的体重和 BMI 值明显高于对照组,血清淋巴细胞计数、红细胞计数、血红蛋白、 白蛋白和总蛋白水平显著高于对照组,PG-SGA 评分明显低于对照组,差异均有统计学意义(P<0. 05)。 结论 卵巢癌患者进 行手术切除和常规静脉化疗后营养不良的风险较高,常规进行 ONS 对提高机体营养和免疫状况具有积极意义。

To evaluate the effects of oral nutritional supplement therapy ONS on nutritional status and immune function for patients with ovarian cancer after surgical resection and routine intravenous chemotherapy and put forward a reasonable nutritional supply scheme. Method A total of 102 patients with ovarian cancer who were admitted to Affiliated Hospital of Jiangnan University from January 2018 to December 2021 were prospectively selected by clinical randomization case-control method and all of them were treated with surgical resection and conventional intravenous chemotherapy. Then they were randomly divided into control group and test group with 51 patients in each group. The control group was given routine nutrition guidance and the test group was given ONS Ensure ® 250 ml 1. 06 kcal containing 0. 0356 g protein per mL produced by Abbott Laboratories in the United States 3 times/ d for 15 weeks. The body mass body mass index BMI serum lymphocyte count erythrocyte count hemoglobin albumin and total protein levels before discharge 3 weeks 9 weeks and 15 weeks after discharge as well as the Patient generated subjective overall assessment PG-SGA score were compared between the two groups. Result 48 patients in the control group and 49 patients in the test group finally completed the clinical follow-up. The general clinical datas of the two groups were comparable P > 0. 05 . The body mass and BMI of the test group were significantly higher than those of the control group after 9 and 15 weeks follow-up the levels of serum lymphocyte count erythrocyte count hemoglobin albumin and total protein were significantly higher than the control group and the PG-SGA score was significantly lower than the control group too P < 0. 05 . Conclusion Patients with ovarian cancer have a higher risk of malnutrition after surgical resection and routine intravenous chemotherapy. Routine ONS is of positive significance to improve the nutritional and immune status of the body which is worthy of clinical application.