目的 探讨强化左旋肉碱和牛磺酸的新型肠内营养配方对肺癌化疗患者的影响,为新型营养配方的研制提供临床 实践依据。 方法 筛选 2021 年 5 月至 2022 年 6 月重庆医科大学附属巴南医院收治的拟行化疗的肺癌患者,随机分为两组。 试 验组给予添加左旋肉碱和牛磺酸的新型肠内营养配方、对照组给予常规整蛋白型肠内营养配方,服用方法均为每日 3 次,每 次 50 g,持续 12 周。 比较两组患者在治疗前后生活质量、营养状况以及化疗期间不良反应发生率有无差异。 结果 最终 83 例 患者纳入试验组,85 例患者纳入对照组。 治疗前两组患者生活质量各领域评分,体质指数、血清总蛋白、白蛋白、血红蛋白指 标,主观整体营养评估量表评分,差异均无统计学意义(P>0. 05)。 治疗后,试验组患者生活质量各领域评分更高,体质指数、 血清总蛋白、白蛋白以及血红蛋白明显高于对照组,主观整体营养评估量表评分更低,营养状况更好,差异有统计学意义(P< 0. 05)。 试验组白细胞不良反应分级低于对照组,胃肠道反应更小、恶性呕吐持续时间短于对照组,差异有统计学意义(P< 0. 05)。 结论 强化左旋肉碱和牛磺酸的新型肠内营养配方可应用于肺癌化疗患者,有利于提高患者生活质量、改善其营养状 况、减轻化疗不良反应。

Objective To explore the effect of a novel enteral nutrition formula fortified with L-carnitine and taurine on patients undergoing chemotherapy for lung cancer to provide clinical practice basis for the development of a novel nutrition formula. Method Lung cancer patients who were admitted to Banan Hospital Affiliated to Chongqing Medical University from May 2021 to June 2022 were screened and randomly divided into two groups. The experimental group was given by a novel enteral nutrition formula supplemented with L-carnitine and taurine and the control group was given by a conventional whole protein enteral nutrition formula. The patients took 50 g of their own formula three times a day for 12 weeks. The quality of their daily life nutritional status and the incidence of toxic and side effects during chemotherapy were compared between the two groups pre- and post- treatment. Result A total of 83 patients were involved in the experimental group and 85 patients were involved in the control group. Before treatment there was no significant statistical difference between the two groups in the scores of quality of life in various fields including body mass index total serum protein albumin hemoglobin and subjective overall nutrition assessment scale P>0. 05 . After treatment the patients in the experimental group obtained higher scores in all fields of quality of life. Especially body mass index total serum protein albumin and hemoglobin were significantly higher than those in the control group. Even the lower all subjective nutrition assessment scale score was the better nutritional status is. The difference was statistically significant P<0. 05 . The grade of leukocyte toxicity and side effects in the experimental group were lower than those in the control group the gastrointestinal reaction was smaller and the duration of malignant vomiting was shorter than that in the control group. The difference was statistically significant P<0. 05 . Conclusion The novel enteral nutrition formula strengthened with L-carnitine and taurine can be applied to lung cancer chemotherapy patients which is conducive to improving their quality of life and their nutritional status and reducing the toxic and side effects of chemotherapy.