大麻二酚(CBD)是植物大麻提取物的主要成分。 CBD 是非精神活性物质, 无成瘾性、毒性低、安全性高。 因其具 有良好的抗炎、抗氧化、神经保护等作用成为研究热点, 已被用于治疗多种难治性癫痫。 CBD 在肿瘤治疗中展现独特优 势, 其机制有:①诱导细胞周期阻滞, 抑制肿瘤细胞增殖;②增加肿瘤细胞活性氧家族水平、诱导线粒体功能紊乱、调控 Bcl-2 家族蛋白、抑制 IAP 家族蛋白功能等多种途径, 促进肿瘤细胞凋亡;③抑制肿瘤细胞迁移和侵袭;④联合其他抗癌治疗发挥更 强的抗肿瘤作用;⑤缓解诸如疼痛、焦虑、抑郁等肿瘤相关症状;⑥可能存在调节肿瘤微环境的作用。 CBD 在多种肿瘤治疗中 展现出良好的抗肿瘤特性, 有望作为一种新的肿瘤治疗药物投入临床使用。 目前 CBD 与肿瘤治疗相关的临床试验主要聚焦 于对晚期肿瘤患者的镇痛治疗, 其直接治疗作用仍有待进一步临床试验。

Cannabidiol CBD is the main component of cannabis extract which is a non - psychoactive substance with non - addictive low toxicity and high safety. CBD has shown unique advantages in tumor therapy and is being used on refractory epilepsy. Its mechanisms include as follows. ① Inducing cell cycle arrest and inhibiting tumor cell proliferation. ② Promoting tumor cell apoptosis through increasing ROS levels in tumor cells inducing mitochondrial dysfunction regulates Bcl-2 family proteins and inhibiting IAP family protein function. ③ Inhibiting tumor cell migration and invasion. ④ In conjunction with other anti - cancer therapies to exert a stronger anti-tumor effect. ⑤Relieve tumor-related symptoms such as pain anxiety and depression. ⑥It may play a role in regulating the tumor microenvironment. CBD has shown good anti - tumor properties in various tumor treatments and is expected to be used as a new tumor treatment drug in clinical practic. At present clinical trials related to CBD and cancer treatment mainly focus on analgesic treatment for patients with advanced tumors and its direct therapeutic effect still needs further clinical trials.