恶性肿瘤由细胞恶性增生所致,严重危害人体健康,威胁生命安全,是全球死亡的主要原因之一,而恶性肿瘤的死 因绝大多数是由肿瘤的侵袭转移所致。 通过肿瘤侵袭-转移级联(IMC),从原发灶转移至远端组织,并成功定植。 IMC 是一个 涉及多因素、多步骤的复杂过程,并通过多种信号通路促进侵袭转移。 植物化学物被证实可抑制这些信号通路的形成,从而 阻断肿瘤的侵袭转移。 此外,肿瘤细胞的耐药性和耐辐射性增强,也是导致肿瘤发生侵袭转移的原因,而 IMC 过程中的上 皮-间质转化(EMT)又会进一步加强肿瘤耐药性和耐辐射性。 鉴于二者的相互促进作用和抗肿瘤治疗出现的不良反应大、疗 效有限的缺点,寻找安全、有效的抗肿瘤侵袭转移和放化疗增敏剂是肿瘤研究中迫切又必要的课题。 研究表明,具有多种生 物活性的植物化学物,单独使用或与抗肿瘤治疗联合应用,可抑制肿瘤转移、增加放化疗敏感性和降低抗肿瘤治疗的不良反 应。 本文对近年来植物化学物在抑制 IMC 过程中多种信号通路和对放化疗增敏领域应用的发展现状及成果进行综述,以期 为植物化学物抗肿瘤侵袭转移的临床应用研究提供参考。

Malignant tumors are caused by the malignant growth of cells which seriously endanger human health and threaten life. Most deaths from malignant tumors are caused by tumor invasion and metastasis. Through the invasion-metastasis cascade IMC tumor cells are transferred from the primary focus to distant tissues and successfully colonized. IMC is a complex process involving multiple factors and steps. Multiple signal pathways can promote tumor invasion and metastasis. Phytochemicals have been proved to block tumor invasion and metastasis by inhibiting the formation of these signal pathways. Epithelial mesenchymal transformation EMT in the IMC process will strengthen tumor drug resistance and radiation resistance. Because of the mutual promotion between tumor invasion and metastasis with drug and radiation resistance and the shortcomings of large side effects and poor effects of anti-tumor therapy it is urgent to find safe and effective drugs with anti - tumor invasion and metastasis and radiochemotherapy sensitization effect. Studies have shown that phytochemicals have a variety of biological activities. If they are used alone or in combination with anti-tumor therapy they can inhibit tumor invasion and metastasis reduce the toxicity of anti - tumor therapy and improve the radiochemotherapy sensitivity. The purpose of this article is to review the current status and developments of phytochemicals as an anti signal pathway in inhibiting IMC antitumor invasion and anti-metastasis therapy in recent years in order to provide ideas for future research on anti-tumor invasion and metastasis of phytochemicals.