肿瘤是世界范围内的主要公共卫生问题,对人类生命和健康具有严重威胁。 维生素 D 缺乏会增加肿瘤的发生风 险。 流行病学证据支持维生素 D 对肿瘤发生风险的保护作用,维生素 D 的抗肿瘤作用主要来自其活性代谢物与受体的结合 而发挥相关生物学功能,但两者之间的关系因肿瘤的部位而有所差异。 meta 分析普遍报道了高维生素 D 状态是乳腺癌、结直 肠癌、肝癌、膀胱癌及肺癌的保护因素(OR= 0. 46~ 0. 92)。 此外,维生素 D 相关基因多态性与肿瘤的关系及其对维生素 D 水 平与肿瘤发生、风险之间关系的影响也引起人们的广泛关注。 维生素 D 受体和维生素 D 合成和降解途径中的单核苷酸多态 性与肿瘤发生、发展风险有关。 本文就维生素 D 代谢、潜在抗癌机制及其与不同肿瘤发生风险关系的研究进展进行综述,并 探索维生素 D 相关基因多态性与肿瘤之间关系,对于未来肿瘤的一级预防提供理论参考依据。

Cancer is a major public health problem worldwide which seriously threatens the life and health of humans. A large body of epidemiological evidence supports a role for vitamin D in the protection of cancer risk. The antitumor effect of vitamin D mainly comes from the binding of its active metabolites to receptors to perform related biological functions but the relationship varies depending on the location of the tumor. Meta-analysis has generally reported high vitamin D status is a protective factor for breast colorectal liver bladder and lung cancers OR= 0. 46-0. 92 . In addition the association of vitamin D-related gene polymorphisms with cancer and its impact on the relationship between vitamin D levels and the risk of cancer has also attracted great attention. Single nucleotide polymorphisms in vitamin D receptors and vitamin D synthesis and degradation pathways are associated with the risk of tumor development and progression. This article reviews the research progress of vitamin D metabolism its potential anti - cancer mechanisms and its relationship with the risk of different cancers and explores the relationship between vitamin D- related gene polymorphisms and different cancers so as to provide a theoretical basis for the primary prevention of cancer in the future.