随着我国诊疗技术的不断提升,肿瘤患者的预期寿命逐渐延长,这也使得肿瘤本身及其治疗所致的并发症日益突 显。 有一类肿瘤患者在病程中出现记忆、注意、执行等功能障碍,即肿瘤相关认知障碍(CRCI),影响患者日常生活,严重降低 生存质量。 这种由肿瘤直接或间接引起的认知障碍迄今为止尚无有效的治疗方法。 近年来,营养干预在肿瘤和认知障碍领 域的进展逐渐引起关注,营养干预改善肿瘤患者的预后和生活质量、改善认知功能等可见相关报道。 鉴于此,营养干预或可 为改善肿瘤相关认知障碍提供了机会。 然而,目前国内外对于营养干预在 CRCI 中的认识仍比较局限,其影响 CRCI 的潜在机 制仍未可知,因此本文拟总结国内外近 10 年相关研究证据,试从衰老与衰弱、神经炎症反应、代谢过程、表观遗传学四个方面 来探讨营养干预影响 CRCI 的潜在机制,为阐明营养干预在肿瘤相关认知障碍的潜在应用价值提供新的思路。

With the continuous improvement of diagnosis and treatment technology the life expectancy of cancer patients is gradually increasing which makes the complications caused by cancer itself and its treatment become increasingly prominent. Cancer related cognitive impairment CRCI is a type of cancer with functional impairment of memory attention and execution during the course of the disease which affects patients􀆶 daily life and severely reduces the quality of life of patients. So far there is still no effective treatment for this cognitive impairment which is directly or indirectly caused by cancer. In recent years the progress of nutrition intervention in the field of cancer and cognitive disorders has gradually attracted attention. It can be seen that nutrition intervention can improve the prognosis and quality of life of cancer patients and improve cognitive function. In view of this nutritional interventions may provide an opportunity to ameliorate cancer related cognitive impairment. However at present the understanding of nutrition intervention in CRCI is still limited and the potential mechanism of its influence on CRCI is still unknown. Therefore this review intends to summarize the relevant research evidence in recent 10 years and try to explore the potential mechanism of nutrition intervention on CRCI from four aspects aging and frailty neuroinflammatory response metabolic process and epigenetics. It provides new ideas for elucidating the potential application value of nutrition intervention in cancer-related cognitive impairment.