脂肪酸是维持人体正常生理功能的必需营养物质,在体内需被相关酶激活后才可以进入正常代谢途径,脂肪酸代 谢失调与肿瘤发生密切相关。 长链酰基辅酶 A 合成酶(ACSLs)负责激活长链脂肪酸, ACSLs 家族包括 5 个成员,分别为 ACSL1、ACSL3、ACSL4、ACSL5、ACSL6,不同亚型具有不同细胞定位及功能,可以催化不同脂类并影响其代谢去路。 ACSLs 通过 调节脂肪酸代谢,广泛参与内质网应激、铁死亡、耐药和肿瘤炎症微环境,ACSLs 在肿瘤中经常去调控,可以影响脂肪酸代 谢,而脂肪酸可以通过激活多种转录因子与基因反应原件结合激活不同的 ACSLs,肿瘤细胞和蛋白泛素化可以调节 ACSLs 基 因的表达,从而导致肿瘤发生代谢紊乱和其他代谢性疾病的发生。 Triacsin C 是一种 ACSLs 抑制剂,对开发抗肿瘤药物有巨大潜 力。 本文就 ACSLs 在细胞中的表达与定位、生理作用、在肿瘤中的功能、分子机制进行综述,结果表明,ACSLs 与肿瘤中的炎症反 应、脂质代谢紊乱、肿瘤侵袭与转移相关,对肿瘤发生、发展具有重要意义,可能成为肿瘤治疗有价值的生物标志物和治疗靶点。

Fatty acids are essential nutrients to maintain normal physiological functions in the body and need to be activated by relevant enzymes in the body before they enter the normal metabolic pathway. While dysregulation of fatty acid metabolism is closely associated with tumorigenesis. Long - chain acyl - CoA synthases ACSLs are responsible for the activation of long - chain fatty acids. The ACSLs family consists of five members ACSL1 ACSL3 ACSL4 ACSL5 and ACSL6 with different isoforms having different cellular localizations which can catalyze different lipids and influence their metabolic routes. ACSLs are extensively involved in endoplasmic reticulum stress iron death drug resistance and tumor inflammatory microenvironment by regulating fatty acid metabolism. And ACSLs are often deregulated in tumors and can affect fatty acid metabolism. However fatty acids can activate different ACSLs by activating multiple transcription factors in combination with gene response elements and tumor cells and protein ubiquitination can regulate the expression of ACSLs genes. This leads to the development of metabolic disorders in tumors and other metabolic diseases. Triacsin C an inhibitor of ACSLs has great potential for the development of antitumor drugs. This article reviews the expression and localization of ACSLs in cells physiological functions functions in tumors and molecular mechanisms. The results indicate that ACSLs are associated with inflammatory response lipid metabolism disorders tumor invasion and metastasis in tumors which are important for tumor development and may become valuable biomarkers and therapeutic targets for tumor therapy.