目的 探讨控制营养状况(CONUT)评分评估上皮性卵巢癌患者生存预后的价值。 方法 回顾性总结 2017 年 1 月至 2020 年 6 月入南京医科大学附属江宁医院确诊上皮性卵巢癌患者共 158 例,采用受试者操作特征(ROC)曲线获得治疗前 CONUT 评分预测总生存(OS)率的最佳截止点,分析患者临床病理因素与 CONUT 评分的关系;分别采用单因素与多因素 Cox 比 例风险模型筛选危险因素,Kaplan-Meier 曲线分析 CONUT 评分与 OS 率的关系。 结果 随访中位时间 35. 0 个月,CONUT 评分 0~ 12 分,ROC 曲线分析显示曲线下面积(AUC)期值为 0. 775,截止点为 2. 7。 将患者分为高分组(≥3 分)71 例和低分组( <3 分)87 例,高分组患者年龄≥58 岁、FIGO 分期Ⅲ~Ⅳ期、中至大量腹水、新辅助化疗+肿瘤细胞减灭术、化疗耐药比例明显高于 低分组(P<0. 05)。 单因素与多因素 Cox 分析显示,CONUT 评分≥3 分是 OS 期的独立危险因素(P<0. 05)。 高分组 OS 率明显低于低分组(P<0. 05)。 结论 上皮性卵巢癌患者 CONUT 评分与患者年龄、FIGO 分期、腹水、临床治疗以及化疗耐药相关,CONUT 评分≥3 分对评估较差的生存预后有较好的应用价值。

Objective To evaluate the prognostic value of controlling nutritional status CONUT score in patients with epithelial ovarian cancer. Method A total of 158 patients with epithelial ovarian cancer into Jiangning Hospital Affiliated to Nanjing Medical University from January 2017 to June 2020 were retrospectively summarized. The optimal cut - off value of CONUT score before treatment for predicting overall survival OS rate was obtained by receiver operator characteristic ROC curve and the relationship between clinicopathological factors and CONUT score was analyzed. Univariate and multivariate Cox proportional hazard models were used to screen risk factors and Kaplan-Meier analysis was used to analyze the correlation between CONUT score and OS rate. Result The median follow-up time was 35. 0 months the CONUT score was 0-12 points the area under the curve AUC was 0. 775 and the cut-off value was 2. 7. The patients were divided into high-score group ≥ 3 points 71 cases and low-score group < 3 87 cases. The age of patients≥ 58 years old in high-score group FIGO stage Ⅲ-Ⅳ moderate to large amount of ascites neoadjuvant chemotherapy + interval debulking surgery and chemotherapy resistance were significantly higher than those in low-score group P < 0. 05 . Univariate and multivariate Cox analysis showed that CONUT score ≥ 3 points was the independent risk factor to OS P < 0. 05 . The OS rate of high-score group was significantly lower than that of low-score group P< 0. 05 . Conclusion CONUT score of patients with epithelial ovarian cancer is related to patients ' age FIGO stage ascites clinical treatment and chemotherapy resistance. CONUT score ≥ 3 has a good application value in evaluating poor prognosis.