近年来,随着对肿瘤细胞的营养方式与代谢路径研究的逐渐深入,饮食在肿瘤进展中的影响受到了广泛关注。 目 前普遍认为,与正常细胞相比,多数肿瘤细胞高度依赖以葡萄糖为底物的有氧糖酵解过程产能,而缺乏利用酮体的能力,于是 通过限制碳水化合物摄入、提升血酮体浓度切断肿瘤细胞的营养来源,进而遏制肿瘤细胞生长及分裂的论点应运而生。 本文 将简明地阐述肿瘤细胞的营养代谢机制,从多个角度探讨低碳水化合物生酮饮食方案对肿瘤细胞产生和代谢的影响。

In recent years the influence of daily diet on tumor progression has received extensive attention with the research on the nutrition method and metabolic pathway in tumor cells much deeper. It is generally recognized that compared with normal cells most tumor cells are highly dependent on the aerobic glycolysis based on glucose to obtain energy whereas unable to utilize amino acids and ketone bodies. Therefore it is proposed to cut off the nutrient source of tumor cells through restricting carbohydrate intake thus restraining tumor cells from growing and divising. This review aims to describe the nutritional and metabolic mechanism of tumor cells concisely and discuss about the effects low-carbohydrate ketogenic diet has on the apparence and metabolism of tumor cells from various perspectives.