肌肉减少症是一种以进行性、广泛性的骨骼肌量减少和功能减退为主要特点的综合征。 在肿瘤患者中常会出现不 同程度的营养不良,表现为体重的下降、骨骼肌量减少、肌力异常以及躯体功能的减退等,进而会导致肌肉减少症甚至是恶液 质,导致患者疗效差、生活质量下降,生存期缩短。 近年来有研究表明,给予 ω-3 多不饱和脂肪酸( ω - 3 polyunsaturated fatty acids, ω-3 PUFAs)干预,对于肿瘤患者肌肉减少症的预防和治疗可能具有积极意义。 ω-3 PUFAs 的抗炎、提高胰岛素的敏感 性以及提高代谢的灵活性和能量利用的作用是改善肿瘤患者骨骼肌状态可能的机制。 近年来肿瘤患者肌肉减少症的相关干 预研究热度较高,但目前已有的关于 ω-3 PUFAs 干预是否可以改善肿瘤患者骨骼肌状态的临床研究较少,且涉及到的评价指 标较少,同时各研究存在结果不一致的情况。 为指导 ω-3 PUFAs 在临床的规范应用,本文对 ω-3 PUFAs 改善肿瘤患者骨骼 肌状态的相关研究作一综述,以期为肿瘤患者肌肉减少症的营养治疗提供一定的理论基础。

Sarcopenia is a syndrome characterized by progressive generalized loss of bone spur muscle mass and function. Poor health maintenance manifested as a decrease in body weight bone spur muscle mass reduction abnormal muscle strength and decline in physical function etc. will enter and lead to muscle loss with a small amount of symptoms or even cachexia resulting in poor curative effect decreased quality of life and shortened life span. Studies in recent years have shown that giving ω-3 PUFAs and fatty acid intervention the effects of ω-3 PUFAs on anti-inflammation improving nutrient sensitivity improving metabolic flexibility and energy utilization are likely to change the bone status of skillful patients mechanisms. In recent years there has been more interest in intervention research related to less muscle loss in brittle people but there are relatively few clinical studies on whether ω-3 PUFAs intervention materials can improve the state of bone spurs in brittle people and there are fewer evaluation indicators involved. Various studies exist where results are inconsistent. In order to guide the standardized application of ω- 3 PUFAs in clinical practice this article reviews the related research on ω-3 PUFAs in modifying the skeletal state of myalgia patients hoping to establish a certain theoretical basis for the nutritional treatment of sarcopenia in patients with arthralgia.