目的 调查分析老年肺癌患者化疗癌因性疲乏的发生率和危险因素。 方法 选取 2020 年 3 月至 2023 年 3 月淮安市 第二人民医院收治的 120 例老年肺癌患者为调查对象,所有患者均接受统一的化疗方案,采用 Piper 疲乏量表对患者进行评 估,统计出现癌因性疲乏患者人数,计算疲乏发生率。 根据患者的疲乏发生情况分为疲乏组(79 例)和正常组(41 例),以单因 素和多因素 Logistic 回归分析老年肺癌化疗癌因性疲乏的危险因素。 结果 120 例老年肺癌患者中有 79 例患者出现癌因性疲 乏,癌因性疲乏发生率为 65. 83%。 经单因素分析显示,疲乏组患者的年龄、肿瘤分期、基础疾病史、并发症发生率高于正常 组,血清白蛋白(ALB)水平低于正常组(P<0. 05)。 多因素分析表明,高龄、肿瘤分期高、合并基础疾病、伴有并发症及低 ALB 水平是老年肺癌化疗癌因性疲乏的独立危险因素。 结论 老年肺癌患者化疗期间普遍出现癌因性疲乏症状,其中高龄、肿瘤分 期高、合并基础疾病、伴有并发症及低 ALB 水平是癌因性疲乏发生的独立危险因素。

Objective To investigate and analyze the incidence and risk factors of chemotherapy induced fatigue in elderly lung cancer patients. Method 120 elderly lung cancer patients admitted to our hospital from March 2020 to March 2023 were selected as the survey subjects. All patients received unified chemotherapy treatment and were evaluated using the Piper fatigue scale. The number of patients with cancer induced fatigue was counted and the incidence of fatigue was calculated. According to the occurrence of fatigue in patients they were divided into a fatigue group and a normal group and the risk factors of cancer induced fatigue in elderly lung cancer patients undergoing chemotherapy were analyzed using univariate and multivariate logistic regression. Result Out of 120 elderly lung cancer patients 79 patients experienced cancer induced fatigue fatigue with an incidence rate of 65. 83%. The patients were divided into a fatigue group 79 cases and a normal group 41 cases . Univariate analysis showed that the age tumor stage basic disease history and incidence of complications of the fatigue group were higher than those of the normal group while serum albumin ALB was lower than that of the normal group P < 0. 05 . Multivariate analysis shows that advanced age high tumor staging comorbidities with underlying diseases complications and low ALB are independent risk factors for cancer related fatigue in elderly patients with lung cancer undergoing chemotherapy. Conclusion Elderly lung cancer patients generally experience cancer induced fatigue symptoms during chemotherapy among which advanced age high tumor staging comorbidities with underlying diseases complications and low ALB are independent risk factors for the occurrence of cancer induced fatigue.