目的 探索肺癌化疗患者味觉改变与其营养状况及癌因性疲乏的相关性。 方法 回顾性分析苏州市中医医院 2021 年 2 月至 2024 年 2 月期间收集的 137 例肺癌化疗患者,应用化疗相关味觉改变量表( CiTAS)、营养风险筛查 2002(NRS 2002)、癌因性疲乏(CFS)状态进行评估,经 Pearson 法和线性回归分析 CiTAS 评分、NRS 2002 评分、CFS 评分相关性,同时,经 中介效应分析三者的关系。 结果 肺癌化疗患者的基本味觉改变评分(15. 52±2. 52)分、味觉异常和味幻觉(9. 12±2. 63)分、进 食困扰(20. 15±2. 35)分、整体味觉改变(12. 35±2. 89)分、CiTAS 总分(57. 13±7. 78)分,NRS 2002 评分(4. 89±2. 22)分,躯体疲 乏(24. 86±2. 84)分、情感疲乏(12. 36±2. 39)分、认知疲乏(11. 78±2. 55)分、CFS 总分(49. 01±6. 60)分。 经 Pearson 法分析,CiTAS 总分与 NRS 2002 评分,躯体疲乏、情感疲乏、认知疲乏、CFS 总分呈正相关;经线性回归分析,NRS 2002 评分、CiTAS 总分 会影响 CFS 总分;经中介效应分析,NRS 2002 评分(β = 0. 469,P<0. 001)与 CiTAS 总分( β = 1. 105,P<0. 001)均可以显著正向 预测 CFS 总分;CiTAS 总分在 NRS 2002 评分、CFS 总分影响中起到部分中介作用,中介效应占总效应比例的 21. 17%。 结论 肺癌化疗患者味觉改变症状明显,处于中重度水平,且会直接影响营养状况及癌因性疲乏,味觉改变越严重,营养状态、癌因性疲 乏越严重,呈正相关,对此需积极开展营养治疗,调整食物口味,适应患者味觉需求,以保证足够营养摄入,改善身心健康状态。

Objective To explore the correlation between taste change its nutritional status and cancer fatigue in lung cancer chemotherapy patients. Method Retrospective analysis of 137 patients with lung cancer chemotherapy collected in Suzhou Hospital of Traditional Chinese Medicine from February 2021 to February 2024 for chemotherapy-related taste change scale CiTAS nutritional risk screening NRS 2002 cancer fatigue CFS status assessment Pearson method and linear regression analysis of CiTAS score NRS 2002 score and CFS score. Result Basic taste change score 15. 52±2. 52 taste abnormalities and taste hallucinations 9. 12± 2. 63 eating distress 20. 15±2. 35 overall taste change 12. 35±2. 89 CiTAS score 57. 13±7. 78 NRS 2002 score 4. 89± 2. 22 physical fatigue 24. 86± 2. 84 emotional fatigue 12. 36± 2. 39 cognitive fatigue 11. 78± 2. 55 CFS score 49. 01± 6. 60 points. Analyzed by the Pearson method total score of CiTAS was positively correlated with NRS 2002 score physical fatigue emotional fatigue cognitive fatigue and CFS total score After a linear regression analysis NRS 2002 The score and the total CiTAS score will affect the total CFS score By the analysis of the mediation effect NRS 2002 Score β = 0. 469 P<0. 001 and total CiTAS score β = 1. 105 P<0. 001 can significantly and positively predict the total CFS score The CiTAS total score plays a partial mediating role in the influence of NRS 2002 score and CFS total score the mediation effect accounted for 21. 17% of the total effect proportion. Conclusion Lung cancer chemotherapy patients taste change symptoms moderate to severe level and will directly affect the nutrition and cancer fatigue taste change the more serious nutritional status cancer fatigue the more serious a positive correlation to actively develop nutrition support adjust food taste to meet the demand of patients to ensure enough nutrition intake improve physical and mental health.