目的 分析肝硬化患者中肌肉和体脂肪水平,探讨肝病严重程度与肝硬化患者肌肉和体脂肪的关系。 方法 采用横 断面研究方法收集 2022 年 11 月至 2023 年 11 月在西南医科大学附属医院住院的肝硬化患者指标,利用 Sliceomatic 5. 0 图像 分析软件测量腹部计算机断层扫描(CT) 在第 3 腰椎水平的骨骼肌指数(L3 -SMI)、内脏脂肪面积(VFA) 和皮下脂肪面积 (SFA),评估老年营养风险指数(GNRI)。 VFA 和 SFA 分别与 L3 -SMI、三头肌皮褶厚度(TSF)、非优势侧上臂中点围度(MAC) 等指标进行相关性分析,比较不同 Child-Pugh 分级和终末期肝病模型(MELD)评分的分组中 CT 所测得的肌肉和体脂肪水 平。 结果 共纳入 203 例肝硬化患者,其中合并肌肉减少症患者 86 例(42. 4%),非肌肉减少症患者 117 例(57. 6%),肝硬化合 并肌肉减少症患者的体质指数(BMI)、手握力(HS)、MAC、TSF、小腿围(CC)、VFA、SFA、内脏脂肪指数(VATI)及皮下脂肪指 数(SATI)低于非肌肉减少症患者(P<0. 05),VFA 与 MAC 的相关性最强( r = 0. 595,P<0. 001),SFA 与 TSF 相关性最强( r = 0. 753,P<0. 001)。 Child-Pugh 评分 C 级的 VFA、SFA、VATI 和 SATI 低于 Child-Pugh 评分 A 级与 B 级(P<0. 05),L3 -SMI 组间 比较无统计学差异;MELD 评分>11 分的上述指标均低于 MELD 评分≤11 分(P<0. 05),L3 -SMI 组间比较无统计学差异。 结 论 肝硬化患者发生肌肉减少症时,体脂肪水平也下降,且随疾病严重程度的增加而下降,但肌肉水平未见显著变化。

Objective To analyze muscle and body fat levels in cirrhotic patients as well as investigate the association between liver disease severity and muscle and body fat in patients with cirrhosis. Method All study participants were cirrhosis patients who were hospitalized at Southwest Medical University's Affiliated Hospital from November 2022 to November 2023. A cross-sectional study was used to collect data on cirrhotic patients' general condition blood routine biochemical tests anthropometric measurements etc. Measurement of skeletal muscle index L3 -SMI visceral fat area VFA and subcutaneous fat area SFA of abdominal CT at the level of the 3rd lumbar vertebrae using Sliceomatic 5. 0 image analysis software. The Geriatric Nutritional Risk Index GNRI was analyzed. VFA and SFA were correlated with L3 - SMI triceps skinfold thickness TSF and mid - arm circumference MAC respectively. To compare the levels of body fat and muscle measured by CT in subgroups with different Child-Pugh classifications and MELD scores. Result A total of 203 patients with liver cirrhosis were included 86 patients with sarcopenia 42. 4% and 117 patients with non-sarcopenia 57. 6% . Body mass index BMI hand grip strength HS MAC TSF calf circumference CC VFA SFA visceral adiposity index VATI and subcutaneous adiposity index SATI were lower in patients with cirrhosis combined with sarcopenia than in patients with non-sarcopenia P<0. 05 . VFA correlating most strongly with MAC r = 0. 595 P<0. 001 and SFA correlating most strongly with TSF r = 0. 753 P<0. 001 . Child-Pugh score grade C had lower VFA SFA VATI and SATI than Child-Pugh score grade A versus B P<0. 05 L3-SMI was not statistically different between groups and all of the above indicators were lower in the MELD score > 11 subgroup than in the MELD score ≤11 subgroup P < 0. 05 and L3 - SMI was again not statistically different between groups. Conclusion When sarcopenia occurred in patients with cirrhosis body fat levels also decreased and decreased with increasing disease severity but no significant changes in muscle levels were observed.