目的 探索在全人群或肿瘤患者中氧化平衡分数(OBS)与牙周炎的关系。 方法 回顾性分析 2009—2012 年美国国 家健康和营养调查数据库中 5980 例参与者的临床资料。 限制性立方样条图被用来描述 OBS 与牙周炎风险的非线性关系。 Logistic 回归分析被用来描述在全人群和肿瘤人群中 OBS、OBS 饮食及 OBS 生活方式与牙周炎风险的关系,并用 OR 和 95%CI 表示。 亚组分析和交互作用分析被用来探索 OBS 及其成分与牙周炎的关系在不同组间的情况。 结果 共有 5980 例参与者纳 入到本研究中,平均年龄为(51. 91±14. 19)岁,其中 3301 例参与者存在牙周炎。 与低 OBS 的参与者相比,高 OBS 的参与者的 牙周炎风险降低(OR= 0. 80,95%CI = 0. 68~ 0. 93),在肿瘤患者中,这项关系更加明显(OR= 0. 66, 95%CI = 0. 48~ 0. 89)。 亚组 分析和交互作用分析结果显示,OBS 与牙周炎的关系受到年龄的影响,年龄≥65 岁的参与者中,OBS 的保护作用更强(OR = 0. 61,95%CI = 0. 43~0. 87)。 结论 OBS 的升高降低牙周炎的发生风险,尤其是在肿瘤患者中。 此外,这项关系还受到年龄的影响,在老年人中,OBS 升高显著降低牙周炎风险。 改善 OBS 相关的饮食模式和生活方式可能有助于降低牙周炎的发生风险。

Objective To explore the relationship between the oxidative balance score OBS and periodontitis. Method A retrospective analysis of clinical data from 5980 participants in the National Health and Nutrition Examination Survey NHANES database from 2009 to 2012 was conducted. We described the nonlinear relationship between OBS and the risk of periodontitis using restricted cubic splines. Logistic regression analysis was used to further describe the association between OBS and its components with the risk of periodontitis. Subgroup and interaction analyses were employed to explore this relationship across different groups. Result The study included 5980 patients with an average age of 51. 91 ± 14. 19 years. Of these 3301 participants had periodontitis. Compared to participants with a low OBS those with a high OBS had a reduced risk of periodontitis OR = 0. 80 95% CI = 0. 68-0. 93 . In patients with cancer this relationship was more pronounced OR = 0. 66 95% CI = 0. 48- 0. 89 . Subgroup and interaction analysis showed that the relationship between OBS and periodontitis was moderated by age with a stronger protective effect of OBS observed in older participants age ≥ 65 years OR = 0. 61 95%CI = 0. 43-0. 87 . Conclusion This study indicates that an increased OBS is associated with a reduced risk of periodontitis and this relationship is influenced by age. In older individuals a higher OBS has a stronger protective effect against the risk of periodontitis. Improving OBS-related diet and lifestyle may help reduce the occurrence and progression of periodontitis.