目的 探讨基于膳食抗炎指数的营养治疗对接受化疗的肺癌患者免疫功能、炎症因子、肿瘤相关疲劳及化疗不良反 应的影响。 方法 选取 2020 年 2 月至 2023 年 12 月于空军军医大学唐都医院接受化疗的肺癌患者 133 例作为研究对象,依据 选取时间不同,将 2020 年 2 月至 2021 年 12 月接受常规饮食管理的 66 例肺癌患者设立为对照组,将 2022 年 1 月至 2023 年 12 月接受基于膳食抗炎指数的营养治疗的 67 例肺癌患者设立为试验组。 比较两组患者化疗前的营养状况、免疫功能、肿瘤疲 乏、炎症因子,观察化疗期间的不良反应。 结果 在化疗 1 个周期后(T1 )、化疗 2 个周期后(T2 )、化疗 4 个周期后(T3 )时点,试 验组的总蛋白(TP)、白蛋白(ALB)、前白蛋白( PA) 水平,CD4 + T 细胞、CD8 + T 细胞计数,以及 CD4 + / CD8 + T 细胞高于对照 组,而超敏 C 反应蛋白(hs-CRP)、白介素-6(IL-6)水平低于对照组(P<0. 05)。 在 T3 时点,试验组的肿瘤疲乏量表(CFS)评 分的躯体疲乏、情感疲乏、认知疲乏维度得分及总分低于对照组(P<0. 05)。 试验组的白细胞减少、血小板减少,恶心呕吐及腹 泻发生率均低于对照组(P<0. 05)。 结论 基于膳食抗炎指数的营养治疗有助于改善接受化疗的肺癌患者的营养状况,并提高 免疫功能和减轻肿瘤疲乏程度,对提高化疗效果具有积极作用。

Objective To investigate the effects of dietary anti - inflammatory index on immune function inflammatory factors cancer-related fatigue and chemotherapy toxicity in lung cancer patients receiving chemotherapy. Method A total of 133 lung cancer patients who received chemotherapy in Tangdu Hospital of Air Force Military Medical University from February 2020 to December 2023 were selected as the study objects. According to different selection times 66 lung cancer patients who received conventional diet management from February 2020 to December 2021 were set as the control group. A total of 67 patients with lung cancer who received nutritional support based on dietary anti-inflammatory index from January 2022 to December 2023 were selected as the experimental group. The nutritional status immune function cancer fatigue and inflammatory factors before chemotherapy were compared and the toxic and side effects during chemotherapy were observed. Result At T1 T2 and T3 TP ALB PA CD4 + CD8 + CD4 + / CD8 + in observation group were higher than those in control group while hs-CRP and IL-6 were lower than those in control group P<0. 05 . At T3 time point the scores of physical fatigue emotional fatigue and cognitive fatigue in the Cancer Fatigue Scale CFS of the experimental group were lower than those of the control group P<0. 05 . The incidence of leukopenia thrombocytopenia nausea vomiting and diarrhea in observation group were lower than those in control group P<0. 05 . Conclusion Nutritional support based on dietary anti-inflammatory index can improve the nutritional status immune function and reduce cancer fatigue in lung cancer patients treated with chemotherapy which has a positive effect on improving the chemotherapy effect.