肿瘤微环境是由肿瘤细胞周围的非肿瘤宿主细胞、非细胞组分、血管系统和可溶性产物等成分所组成的复杂系 统,在肿瘤的发生和进展中发挥着重要作用。 氨基酸是蛋白质合成的底物,也是能量和营养的重要来源。 越来越多的证据表 明,氨基酸代谢通过调控肿瘤微环境影响肿瘤的生长、转移等多个生物学过程,并与肿瘤免疫和治疗耐药性紧密相关。 靶向 氨基酸代谢治疗方案包括:抑制氨基酸转运体活性、调控氨基酸生物合成以及改良氨基酸膳食疗法,目前已取得显著成果,但 仍有许多问题亟待解决。 本文综述了氨基酸代谢对肿瘤微环境中免疫细胞、肿瘤相关成纤维细胞和其他成分的影响,并总结 了近年来靶向氨基酸代谢治疗肿瘤的相关研究,旨在为靶向氨基酸代谢创新肿瘤治疗方案,促进肿瘤治疗效果和降低肿瘤治 疗耐药性提供研究基础。

The tumor microenvironment is a complex system composed of non-tumor host cells around tumor cells non-cellular components vascular system and soluble products which plays an important role in the initiation and progression of tumor. Components in the tumor microenvironment as therapeutic targets for tumors have attracted extensive research interest. Amino acids are the substrates for protein synthesis and are a vital source of energy and nutrients. More and more evidence indicates that amino acid metabolism affects tumor growth metastasis and other biological processes through the regulation of tumor microenvironment and is closely related to tumor immunity and drug resistance. At present dietary therapies targeting amino acid metabolism including inhibition of amino acids transporter activity regulation of amino acids biosynthesis and amino acids modified dietary have had remarkable achievements however there are still many problems to be solved. In this paper the effects of amino acid metabolism on immune cells tumor - associated fibroblasts and other components in tumor microenvironment were reviewed and studies about targeting amino acid metabolism for tumor therapy in recent years were summarized. We are aimed at providing research basis for better therapy increased therapeutic effect and less drug resistance.