肿瘤代谢以有氧糖酵解为主要特征，同时伴随氨基酸、脂质的代谢异常，是肿瘤发生、发展的基础。肿瘤特殊的代谢 模式不仅能满足肿瘤细胞快速生长的物质能量需求，还使肿瘤在缺氧酸性微环境中获得生存优势，在诱导肿瘤基因突变、促进增 殖转移、抑制周围免疫等方面发挥重要作用。这种代谢模式为肿瘤生长及侵袭提供了良好的条件，也成为近年来的研究热点。 中医血瘀证是晚期肿瘤患者的主要证型，其病理机制与代谢障碍十分相似，因而活血药治疗肿瘤的作用机制被认为与调控肿瘤 代谢有关。现代研究显示，活血药具有调节代谢酶及代谢通路相关蛋白的活性，影响线粒体功能，降低肿瘤细胞葡萄糖等营养物 质的摄入，抑制有氧糖酵解，减少乳酸生成，改变肿瘤乏氧环境，抑制血管生成等作用，为活血药调控肿瘤代谢的作用提供了证据。 本文通过探讨活血药对肿瘤代谢的调控作用，并阐述活血药的抗肿瘤作用机制，为后续研究提供思路，以期指导活血药的临床应用。

Tumor metabolism is characterized by aerobic glycolysis with metabolic disorder of amino acid and lipid, which is the solid foundation of tumorigenesis. The special metabolic pattern can not only support the rapid growth of cancer, but also benefit tumor from the hypoxia and acidic surrounding environment, contributing to induce gene mutation, promote proliferation and metastasis and suppress immunity, which provides a proper condition to tumor development.Tumor metabolism becomes recent hotspot in research correspondingly. Blood stasis is a common syndrome of traditional Chinese medicine among advanced cancer patients. The pathological mechanism of blood stasis is similar to metabolic disorder. Thus, the mechanism of activating blood circulation in treating cancer was considered to be related to regulate tumor metabolism. Researches report that Chinese medicine for activating blood circulation could regulate the activities of metabolic enzymes and metabolic pathway⁃related proteins, affect mitochondrial function, reduce the intake of nutrients such as glucose in cancer cells, inhibit aerobic glycolysis, reduce lactic acid production, change the hypoxic environment of tumors, and inhibit angiogenesis, which provide evidence for the mechanism of Chinese medicine for activating blood circulation regulating tumor metabolism. In this paper, the mechanism of traditional Chinese medicine activating blood drugs in treating tumor was reviewed and discussed via regulating tumor metabolism, which contributes to elucidating the anti⁃tumor mechanism of activating blood drugs, provides a new direction for the further research and guide the application of Chinese medicine for activating blood circulation in tumor treatment.