注射用多种维生素(13)是一种同时含有 9 种水溶性维生素和 4 种脂溶性维生素的复方维生素制剂,临床主要用于 接受肠外营养的成人和 11 岁及以上儿童维生素缺乏的预防。 与注射用多种维生素(12)相比,注射用多种维生素(13)添加了 维生素 K,因为维生素 K 在肠外营养中具有调节凝血、维持骨骼健康以及其他方面的作用。 注射用多种维生素(13)最早于 2003 年在美国上市,但其中国上市时间为 2020 年末,国内临床医师用药经验较少。 2015 年,中华医学会肠外肠内营养学分会 发布了《维生素制剂临床应用专家共识》,对各种临床场景下维生素的补充,以及维生素常用临床制剂的使用方法均做了相应 推荐。 近年来,维生素在临床上的应用取得了许多新的进展。 因此,为促进中国医师规范使用注射用多种维生素(13),提高 对患者维生素代谢状况评估的认识及加强对维生素缺乏的了解,进一步推动我国注射用多种维生素研究的开展,中国抗癌协 会肿瘤营养专业委员会根据我国营养诊疗现状、国内外发表的循证医学证据,建立各项指标的评价方法和内容,在 2015 年 《维生素制剂临床应用专家共识》的基础上,结合国际上相关指南,通过专家共识法形成 15 条推荐意见,涉及注射用多种维生 素(13)的必要性、全面性、临床应用,及维生素的检测和监测等方面。

Multivitamin for injection 13 is a compound vitamin preparation containing both 9 water-soluble vitamins and 4 fat-soluble vitamins which is used clinically for the prevention of vitamin deficiency in adults receiving parenteral nutrition and children over 11 years of age. Compared to Multivitamin for injection 12 vitamin K has been added for regulating coagulation maintaining bone health and other aspects in parenteral nutrition. Multivitamin for injection 13 was first marketed in the United States in 2003. However it has been marketed in China in late 2020 so domestic clinicians might have little experience with the injection. In 2015 Chinese Society of Parenteral and Enteral Nutrition issued Expert Consensus on Clinical Application of Vitamin Preparations which provided recommendations on vitamin supplementation in various clinical scenarios as well as the use of common clinical preparations of vitamins. In recent years many new advances have been made in the clinical application of vitamins. Therefore in order to promote the standardized use of Multivitamin for injection 13 by Chinese physicians improve the understanding of the assessment of patients' vitamin metabolism and enhance the understanding of vitamin deficiency and further promote the development of research on multivitamins injections in China Chinese Society of Nutritional Oncology CSNO established the evaluation methods and contents of various indicators according to the current situation of nutritional diagnosis and treatment in China and evidence-based medical evidence published at home and abroad. Based on the 2015 Expert Consensus on Clinical Application of Vitamin Preparations and relevant international guidelines CSNO formed 15 recommendations through the expert consensus method involving the necessity comprehensiveness clinical application of Multivitamin for injection 13 and detection and monitoring of vitamins.