肿瘤大剂量维生素 C(HDVC)治疗疗效并不稳定,需要精准强化治疗。 然而,目前在全世界范围内缺乏肿瘤 HDVC 规范化治疗方案,对肿瘤 HDVC 精准强化治疗也缺乏共识,严重影响肿瘤 HDVC 治疗效果和临床应用。 中国抗癌协会营养治 疗专业委员会、中国抗癌协会中西整合控瘤新药研究专业委员会和中国老年保健协会营养代谢分会部分对肿瘤 HDVC 治疗 具有较丰富经验的专家,对肿瘤 HDVC 治疗机制、HDVC 药代动力学特征进行了深入讨论,并就肿瘤 HDVC 适应证和禁忌证、 临床治疗优势方案、不良反应预防和治疗、敏感性精准治疗代谢分子表型、强化治疗策略和疗效监测等形成了共识。 肿瘤 HDVC 治疗专家共识将有助于提高肿瘤 HDVC 治疗规范化水平和疗效。

The efficacy of high - dose vitamin C HDVC treatment for tumors is fragile and requires precise and intensified treatment. However there is not only an absence of standardized therapeutic schedule of HDVC for cancers but also a lack of high-quality guidelines for precise and intensive treatment of HDVC for tumors which seriously affects the therapeutic effect and clinical application of HDVC. Based on in-depth discussions on the anti-tumor mechanisms and the pharmacokinetic characteristics of of HDVC experts with rich experience in the Nutrition Therapy Professional Committee of China Anti - Cancer Association the Research Committee of New Anti-Cancer Drugs for Chinese and Western Integrated Tumor Control and the Nutrition Metabolism Branch of China Elderly Care Association have reached a consensus on the indications and contraindications of HDVC clinical advantage administration the prevention and treatment of side effects the sensitivity and precision treatment of metabolic molecular phenotype the intensive treatment strategy and efficacy monitoring. This consensus will help improve the the standardization and efficacy of of high dose vitamin C treatment against cancer.