术后PNI在胃癌患者预后评估中的临床价值

吴平; 杜仁佳; 俞筠; 葛晓松

doi:10.16689/j.cnki.cn11-9349/r.2020.03.012

肿瘤代谢与营养电子杂志 >

2020 , Vol. 7 >Issue 3: 312 - 316

DOI: https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.012

论著

术后PNI在胃癌患者预后评估中的临床价值

吴平 ,
杜仁佳 ,
俞筠 ,
葛晓松

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1.江南大学附属医院临床营养科，江苏无锡 214062；2.江南大学附属医院肿瘤内科，江苏无锡 214062

网络出版日期: 2021-04-12

基金资助

国家自然科学基金项目（81502042）

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Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients

Wu Ping ,
Du Renjia ,
Yu Yun ,
Ge Xiaosong

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1.Department of Clinical Nutrition, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China；2.Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214062, Jiangsu, China

Online published: 2021-04-12

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摘要

目的探讨术后PNI在胃癌患者预后评估中的临床价值。方法回顾性分析术后胃癌Ⅲ期患者91例，根据术后、首次化疗前的外周血液指标计算出PNI、外周血中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身炎症指数（SII）等营养综合指标，通过ROC曲线计算出PNI最佳截断值。根据PNI最佳截断值将其分为低PNI组（PNI<42.3）和高PNI组（PNI≥42.3），根据PNI分组预测胃癌患者的预后。应用Cox回归模型进行单因素回归分析和多因素分析。结果多因素分析结果显示术后PNI（P=0.004）及分期（P=0.009）是影响胃癌患者总生存时间的独立预后因素。结论术后PNI是预测胃癌患者预后的独立因素，且低PNI和高分期与患者预后不良相关。

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吴平 , 杜仁佳 , 俞筠 , 葛晓松 . 术后PNI在胃癌患者预后评估中的临床价值[J]. 肿瘤代谢与营养电子杂志, 2020 , 7(3) : 312 -316 . DOI: 10.16689/j.cnki.cn11-9349/r.2020.03.012

Abstract

Objective The prognostic nutritional index(PNI) is used as a prognostic factor in gastric cancer(GC). Through this retrospective study, we aim to investigate the relationship between the postoperative PNI and prognosis of patients with stage Ⅲ GC. Methods The subjects of this retrospective study were 91 patients who underwent resection for stage Ⅲ GC, according to the first chemotherapy after surgery, calculated nutrient comprehensive index, such as PNI, NLR, PLR, SII. Time-dependent receiver operating characteristic curve analyses were used to assess discrimination ability and to determine the optimal cut-off values. Results According to the optimal cut-off value, they were divided into the low PNI group (PNI<42.3) and the high PNI group (PNI≥42.3).According to the staging, they were divided into Ⅲa, Ⅲb and Ⅲc three substages. All the inflammation-based and/or the nutritional markers of patients of stage Ⅲ GC, multivariate analyses demonstrated PNI and staging were independent prognostic factors for OS (P=0.004 and P=0.009, respectively). Conclusion PNI is an independent prognostic factor for the prognosis of postoperative chemotherapy patients with gastric cancer, and low PNI and high sub-staging were associated with poor prognosis.

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