1Department of Hematology Hebei PetroChina Central Hospital Langfang 065000 Hebei China
2Department 2 of Neurology Hebei
PetroChina Central Hospital Langfang 065000 Hebei China
Abstract：Objective To discuss the correlation between serum fibroblast growth factor receptor 2 FGFR2 cellular
communication network 1 CCN1 and prognosis in patients with multiple myeloma MM . Method A total of 104 newly diagnosed
MM patients who received treatment in Hebei PetroChina Central Hospital from September 2020 to January 2022 were selected as the
study group and 106 healthy people of the same age who passed the health examination test in our hospital were selected as the control
group. According to the follow-up results of prognosis patients in the study group were classified into a survival group of 62 cases and
a death group of 42 cases. ELISA method was used to detect the serum FGFR2 and CCN1 in patients. Pearson analysis analyzed the
correlation between serum FGFR2 and CCN1 levels and age and ISS stage of patients. The risk factors of death in MM patients were
analyzed by multivariate Cox regression. ROC curves were used to analyze the diagnostic value of serum FGFR2 and CCN1 levels in the
mortality of MM patients. The Kaplan-Meier method was used to analyze the relationship between serum FGFR2 and CCN1 levels and
the three-year survival rate of MM patients. Result For the control group the study group had clearly higher serum FGFR2 and clearly
higher CCN1 P< 0. 05 . For the survival group the death group had clearly higher serum FGFR2 and clearly higher CCN1 P<
0. 05 . The differences in age and ISS staging between the survival group and the death group were statistically clear P< 0. 05 .
Serum FGFR2 level was positively correlated with ISS stage and serum CCN1 level was negatively correlated with ISS stage P<
0. 05 . FGFR2 CCN1 age and ISS stage were independent risk factors for mortality in patients with MM P<0. 05 . The joint of
serum FGFR2 and CCN1 had an AUC of 0. 953 for diagnosing death in MM patients. The joint diagnosis was superior to individual diagnosis Z= 3. 513 3. 237 P< 0. 05 . The three-year survival rate of patients with high serum FGFR2 was lower than that of
patients with low serum FGFR2 and the three-year survival rate of patients with low serum CCN1 was lower than that of patients with
high serum CCN1 P < 0. 05 . Conclusion Serum FGFR2 is upregulated and CCN1 is downregulated in MM patients they are
associated with prognosis. The joint of the two has certain value in diagnosing the death of MM patients.
1刘 方,1王宁方,1尤月明,1张东东,1蔡卓纹,1蔡芳芳,2赵鹏浩. 多发性骨髓瘤患者血清成纤维细胞生长因子受体 2、
细胞通信网络因子 1 表达及其与预后的关系[J]. 肿瘤代谢与营养电子杂志, 2025, 12(6): 786-793.
1Liu Fang,1Wang Ningfang,1You Yueming,1Zhang Dongdong,1Cai Zhuowen,1Cai Fangfang,2Zhao Penghao. The expression of serum FGFR2 and CCN1 in patients with multiple myeloma and their relationship with prognosis. Electron J Metab Nutr Cancer, 2025, 12(6): 786-793.
